![]() ![]() Results of recent investigations with colchicine and physostigmine. Actual Chim Ther 16:13–35īrossi A (1990) Bioactive alkaloids. Academic Press, New York, p 125īrossi A (1988) Optically active alkaloids and unnatural enantiomers: some recent developments. In: Brossi A, Cordell GA (eds) The alkaloids, vol 41. Dorling Kindersley, Londonīoye O, Brossi A (1992) Tropolonic colchicum alkaloids and allo congeners. Schweiz Med Wochenschr 127:1168–1176īown D (1995) Encyclopaedia of herbs and their uses. Epidemiology, clinical aspects and histopathology. Vestn Dermatol Venerol 42:87–88īohn S, Buchner S, Itin P (1997) Erythema nodosum: 112 cases. Thompson and Morgan, Jacksonīodanov VA, Ryzkova GF (1968) Treatment of condylomata acuminata with omain (colchamine). ![]() J Drugs Dermatol 4:196–204īird R (1990) Growing from seed, vol 4. Indian J Pharmaceut Sci 68:806īibas R, Gaspar NK, Ramos-e-Silva M (2005) Colchicine for dermatologic diseases. Ann Pharm Fr 43:345īharathi P, Philomina D, Chakkaravarthi S (2006) Estimation of colchicine in six different species of Gloriosa grown in vivo. S Chand, New Delhiīellet P, Gaignault JC (1985) Gloriosa superba as a source of colchicine substances. Med Res Rev 28:155–183īehl PN, Captain RM, Bedi BMS, Gupta S (1966) Skin-irritant and sensitizing plants found in India. J Biol Chem 259:7391–7398ībattacbaryya B, Panda D, Gupta S, Banerjee M (2008) Anti-mitotic activity of colchicine and the structural basis for its interaction with tubulin. Med Radiol 24:44–49īane S, Puett D, Macdonald TL, Williams RC (1984) Binding to tubulin of the colchicine analog 2-methoxy-5-(2’,3’,4’-trimethoxyphenyl) tropone. Med Radiol 22:70īagecheva MA (1979) Use of colchamine ointment in the radiation therapy of skin cancer. Int J Dermatol 22:566–569Īsliaev LA, Poluektov IA, Gatsula LN, Otyrko AG, Krugovov BA (1977) Increasing the radiosensitivity of skin cancer with colchamine ointment. Biochemistry 37:8356–8368Īram H (1983) Colchicine in dermatologic therapy. Biochemistry 23:1742Īndreu JM, Ramirez BP, Gorbunoff MJ, Ayala D, Timasheff SN (1998) Role of the colchicine ring A and its methoxy groups in the binding to tubulin and microtubule inhibition. J Dermatol 31:741–747Īndreu JM, Gorbunoff MJ, Lee JC, Timashelf SN (1984) Interaction of tubulin with bifunctional colchicine analogs: an equilibrium study. J Rheumatol 21:383Īnan T, Imamura T, Yokoyama S, Fujiwara S (2004) Erythema nodosum and granulomatous lesions preceding acute myelomonocytic leukemia. Dermatol Online J 11:3Īmoura Z, Schermann JM, Wechsler B, Zerah X, Godeau P (1994) Transplacental passage of colchicine in familial Mediterranean fever. Phytochem Anal 15:27Īl-Waiz M, Sharquie KE, A-Qaissi MH, Hayani RK (2005) Colchicine and benzathine penicillin in the treatment of Behçet disease: a case comparative study. hierosolymitanum (Colchicaceae) comparison between two analytical methods. Circulation 97:2183–2185Īlali F, Tawaha K, Qasaymch RM (2004) Determination of colchicines in Colchicum steveni and C. It is used widely off-label by naturopaths for a number of treatments, including the treatment of back pain and also used as an anti-inflammatory agent for long-term treatment of Behcet’s disease.Īdler Y, Finkelstein Y, Guindo J, Rodriguez A, Shoenfeld Y, Genis AB, Sagie A, Bayes de Luna A, Spodick H (1998) Colchicine treatment for recurrent pericarditis. In neurons, axoplasmic transport is disrupted by colchicine. Colchicine poisoning has been reported in patients with kidney or liver failure. Colchicine itself is too toxic for human use as an anti-tumour drug and hence its derivatives have been used. It is also being investigated for its use as an anti-cancer drug. It is used to treat rheumatic complaints, especially gout, also prescribed for its cathartic and antiemetic effects and also in initial treatment for pericarditis. The biosynthesis of colchicine involves amino acid precursors, phenylalanine and tyrosine. Natural (−)-colchicine has only one stereogenic centre: carbon-7. These plants are not available in sufficient quantities to warrant any commercial utilization. Colchicine, among the Indian medicinal plants, is contained in the corms of Colchicum luteum and the seeds of Iphigenia, to the extent of about 0.25 and 0.9 % respectively. Natural (−)-(a S, 7 S)-colchicine, an alkaloid and toxic natural product is a secondary plant metabolite, obtained from Colchicum autumnale also known as ‘meadow saffron’. ![]()
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